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Reserve concomitant prescribing of benzodiazepines or other CNS depressants in patients in methadone remedy to those for whom alternatives to benzodiazepines or other CNS depressants are inadequate.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â€